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<Original Article> The Effects of Epalrestat on Subjective Symptoms and Vibratory Threshold in Type 2 Diabetic Patients with Neuropathy
https://doi.org/10.34429/00003046
https://doi.org/10.34429/00003046219e7380-1b25-4523-98ce-8c545fb271b2
名前 / ファイル | ライセンス | アクション |
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AN10044054_12_02_02.pdf (673.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | <Original Article> The Effects of Epalrestat on Subjective Symptoms and Vibratory Threshold in Type 2 Diabetic Patients with Neuropathy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Epalrestat | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Aldose reductase inhibitor | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Diabetic neuropathy | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Vibratory threshold | |||||
キーワード | ||||||
言語 | en | |||||
主題 | SMV-5 vibrometer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003046 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
Tawata, Masato
× Tawata, Masato× Aida, Kaoru× Inoue, Masaharu× Kurihara, Akihiro× Iwase, Eiichi× Gan, Naoya× Onaya, Toshimasa |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | We evaluated the effects of epalrestat on subjective symptoms and vibration sensation in type 2 diabetic patients with neuropathy. The patients were administered epalrestat 150 mg/day orally in three divided doses for 3 months (treatment period), and the agent was discontinued for 3 months (washout period). Epalrestat relieved numbness in 12 of 16 patients after the treatment period, and numbness worsened in 5 of 11 patients after the washout period. Chi-square analysis revealed significant effects of epalrestat on numbness (p<0.001) and also on other symptoms (p<0.05). Vibration sensation was evaluated by measuring vibratory threshold using an SMV-5 vibrometer. The vibratory threshold significantly decreased in the upper (p<0.05) and the lower (p<0.01) extremities after the treatment period and increased in the lower extremity (p<0.05) after the washout period by paired t-test. There was no significant change in glycosylated hemoglobin as a whole during the study. These observations confirm that epalrestat relieves subjective symptoms and improves vibration sensation in type 2 diabetic patients with neuropathy without affecting glycemic control. | |||||
言語 | en | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
ja : 山梨医科大学雑誌 en : Yamanashi medical journal 巻 12, 号 2, p. 45-51, 発行日 1997 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |