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<Original Article> Optimal Dose of Continuous Interleukin-2 (IL-2) Infusion Together with Intermittent Adriamycin Injection to the Hepatic Artery in Advanced Hepatocellular Carcinoma Patients
https://doi.org/10.34429/00003089
https://doi.org/10.34429/000030893d6fdd24-a568-4173-a9ff-8a0b12a31991
名前 / ファイル | ライセンス | アクション |
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AN10044054_09_04_03.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
タイトル | <Original Article> Optimal Dose of Continuous Interleukin-2 (IL-2) Infusion Together with Intermittent Adriamycin Injection to the Hepatic Artery in Advanced Hepatocellular Carcinoma Patients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Hepatocellular carcinoma | |||||
キーワード | ||||||
主題 | Interleukin-2 | |||||
キーワード | ||||||
主題 | Adriamycin | |||||
キーワード | ||||||
主題 | Immunochemotherapy | |||||
キーワード | ||||||
主題 | Hepatic arterial | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003089 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
IIZUKA, Hidehiko
× IIZUKA, Hidehiko× YAMAMOTO, Masayuki× MATSUMOTO, Yoshiro |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | To determine the appropriate hepatic arterial infusion dose of IL-2 to obtain long-lasting direct response in hepatocellular carcinorna (HCC), we analyzed deleterious factors after various intervals of direct tumor response to immunochemotherapy using adriamycin (ADR). The direct tumor response, survival rate, and changes in peripheral NK activity of 3 groups of advanced HCC patients were compared. Seventeen patients received continuous infusion of IL-2 (0.35×10^6 JRU/day) and intermittent injections of ADR emulsion (10mg) via the hepatic artery after cannulation. Six patients received IL-2 infusion for less than 6 months because of new lesions or side effects of IL-2 (IL-2 ineffective group), and 11 for more than 6 months (IL-2 + ADR group). Seven patients received the ADR emulsion therapy alone (ADR group). In the IL-2 + ADR group, excellent direct effect on liver tumors accompanied by increase in peripheral NK activity was observed. Four patients in the IL-2 + ADR group showed complete remission (CR) and 2 partial remission (PR) of liver tumors. However, long-term observation of NK activity revealed intractable decrease after the 6th to 8th month despite an increase in IL-2 dose, and the survival rate was not higher than that in the ADR group. The ADR group did not show increase of NK levels but 2 patients showed PR. This refractory decrease in the NK activity is probably due to changes of the immunological status following continuous high-dose infusion of IL-2. The appropriate dose for IL-2 infusion, which varies with changes in NK activity after CR is obtained, should be the minimum dose which maintains high NK activity in peripheral lymphocytes, so that rebound phenomenon is not induced. | |||||
出版者 | ||||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
山梨医科大学雑誌 en : 山梨医科大学雑誌 巻 9, 号 4, p. 143-154, 発行日 1994 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |