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<Original Article> Biological Monitoring of Exposure to Organic Solvent Vapors I. A Physiological Simulation Model of m-Xylene Pharmacokinetics in Man
https://doi.org/10.34429/00003151
https://doi.org/10.34429/00003151ab1f4dfa-6ae3-45a5-ba13-d6546b91ed9d
名前 / ファイル | ライセンス | アクション |
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AN10044054_06_03_01.pdf (804.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
タイトル | <Original Article> Biological Monitoring of Exposure to Organic Solvent Vapors I. A Physiological Simulation Model of m-Xylene Pharmacokinetics in Man | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Physiologically based pharmacokinetic model | |||||
キーワード | ||||||
主題 | m-Xylene | |||||
キーワード | ||||||
主題 | m-Methyl hippuric acid | |||||
キーワード | ||||||
主題 | Michaelis-Menten type metabolism | |||||
キーワード | ||||||
主題 | Animal scale-up | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003151 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
KANEKO, Takashi
× KANEKO, Takashi× ENDOH, Kazushi× SATO, Akio |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | A physiological pharmacokinetic model of the transfer of organic solvents in the human body was developed. The model was comprised of seven compartments, i.e., lungs, vessel-rich tissues, vessel-poor tissues, muscles, fat tissues, gastrointestinal tissues, and liver, each being connected to the others by blood flow. The transfer of organic solvents was expressed by simultanfous differential equations, which were then solved numerically by a personal computer using a slmple spreadsheet program. m-Xylene was used as the representative organic solvent. Partition coefficients of m-xylene between blood and air and between body tissue and blood were experimentally determined with blood and tissues of rats. The metabolic constants (Vmax and Km) of m-xylene metabolism and the excretion rate constant of m-methyl hippuric acid (m-MHA) were also determined using rats. These animal data were scaled up and used as the simulation parameters for humans. The results of the simulation of human exposure to m-xylene were essentially in agreement with human experimental data. | |||||
出版者 | ||||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
山梨医科大学雑誌 en : 山梨医科大学雑誌 巻 6, 号 3, p. 127-135, 発行日 1991 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |