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<Original Article> Biological Monitoring of Exposure to Organic Solvent Vapors II. Simulation Studies using a Physiological Pharmacokinetic Model for m-Xylene
https://doi.org/10.34429/00003152
https://doi.org/10.34429/0000315203ff5eca-7279-4d2d-bfd2-624a8acdba60
名前 / ファイル | ライセンス | アクション |
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AN10044054_06_03_02.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
タイトル | <Original Article> Biological Monitoring of Exposure to Organic Solvent Vapors II. Simulation Studies using a Physiological Pharmacokinetic Model for m-Xylene | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Physiologically based pharmacokinetic model | |||||
キーワード | ||||||
主題 | m-Xylene | |||||
キーワード | ||||||
主題 | m-Methyl hippuric acid | |||||
キーワード | ||||||
主題 | External and internal doses | |||||
キーワード | ||||||
主題 | Biological exposure monitoring | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003152 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
KANEKO, Takashi
× KANEKO, Takashi× ENDOH, Kazushi× SATO, Akio |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The relationship between external and internal doses of m-xylene and the effects of body weight, body fat content, sex, and physical activity on the pharmacokinetics of m-xylene were studied using a physiological simulation model. 1. At low exposure concentrations, equal time-weighted average (TWA) concentrations gave almost the same internal dose of m-xylene. 2. The m-xylene concentration in the blood increased continuously with increasing m-xylene concentration in inhaled air. By contrast, the excretion rate of m-methyl hippuric acid (m-MHA) in the urine approached a plateau with increasing m-xylene exposure concentration. 3. The larger the body size, the larger the amount of m-xylene absorbed. However, no significant change was found in m-xylene concentration in the blood with increase in body size. By contrast,the amounts of m-MHA excreted in the urine varied with body size: the larger the bedy size, the greater was the rate of urinary m-MHA excretion. 4. Both m-xylene concentration in the blood and the rate of urinary m-MHA excretion were higher in a slim than in an obese man during exposure, but this relationship was reversed in due course of time after exposure. 5. The physical activity (50 W) during exposure greatly increased the blood concentration of m-xylene as well as the rate of urinary m-MHA excretion. 6. The concentration of m-xylene in the blood during exposure was lower in women than in men, while the opposite was true starting about 10 hours after the end of exposure. The rate of m-MHA excretion in the urine was lower in women than in men both during and after exposure. | |||||
出版者 | ||||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
山梨医科大学雑誌 en : 山梨医科大学雑誌 巻 6, 号 3, p. 137-149, 発行日 1991 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |