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<Review> Effect of Aging on the Immune System
https://doi.org/10.34429/00003187
https://doi.org/10.34429/00003187cf506fac-1c0d-4e3e-ad85-076d7c86a1ce
名前 / ファイル | ライセンス | アクション |
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AN10044054_05_01_01.pdf (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
タイトル | <Review> Effect of Aging on the Immune System | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Aging | |||||
キーワード | ||||||
主題 | B cells | |||||
キーワード | ||||||
主題 | T cells | |||||
キーワード | ||||||
主題 | Thymus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003187 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
FUKAZAWA, Yoshimura
× FUKAZAWA, Yoshimura× KAGAYA, Keiko |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Host defense mechanisms against microbial and viral infections as well as neoplastic cells constitute a close network, with phagocytes, natural killer (NK) cells, immunocytes including T and B cells, and cytokines released from and interacting with these cells. Although aging is accompanied by many changes in the immune system, it is unlikely that all immune cells and systems age at equal rates. Suffice to say, involution of the thymus plays one of major roles in immune senescence. Related to this event are the altered number and functions of T cell subpopulations involved in immunoregulation, a decrease in the immune response by both cell-mediated and humoral branches of the immune system, and an increase in autoimmune activity. The clinical implications of these changes are the elderly person's increased susceptibility to infections such as pneumococcal pneumonia, influenza and tuberculosis. Other changes include an increased susceptibility to heoplasms and perhaps acceleration of the aging process by increased autoimmune activity and immune complexes. The functions of macrophages, PMN, NK cells, and also the complement system are not seriously impaired with age. The evidence that lymphoid progenitors in bone marrow cells from young animals are able to differentiate into lymphoid cells in the aging anirnal, and that involution of thymus may be restored by manipulation of the endocrine system, suggest that there may be a potential for reconstitution of some immune defects in aged individuals by grafting or treatment with drugs to control various age-related diseases, including cancer. | |||||
出版者 | ||||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
山梨医科大学雑誌 en : 山梨医科大学雑誌 巻 5, 号 1, p. 1-18, 発行日 1990 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |