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<Original Article> In vitro Production of Tumor Necrosis Factor (TNFα/Cachectin) from Human Peripheral Blood Monocytes Stimulated with Bacillus Calmette-Guerin. - A Possible Mechanism of BCG Therapy
https://doi.org/10.34429/00003199
https://doi.org/10.34429/00003199473d6641-66dc-445b-8fa3-98e35abb266d
名前 / ファイル | ライセンス | アクション |
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AN10044054_04_04_03.pdf (634.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
タイトル | <Original Article> In vitro Production of Tumor Necrosis Factor (TNFα/Cachectin) from Human Peripheral Blood Monocytes Stimulated with Bacillus Calmette-Guerin. - A Possible Mechanism of BCG Therapy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | tumor necrosis factor | |||||
キーワード | ||||||
主題 | Bacillus Calmette-Guerin | |||||
キーワード | ||||||
主題 | human monocytes | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003199 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
YABUSAKI, Noboru
× YABUSAKI, Noboru× KOMATSU, Hideki× UENO, Akira× TASAKA, Kachio |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Healthy human peripheral mononuclear cells cultured with bacillus Calmette-Guerin (BCG) alone produced cytotoxic factor that lysed L.P3 murine fibroblast cells after 2 hours of culture, and the production reached a peak after 24 to 48 hours. Since L.P3 cells are sensitive both to tumor necrosis factor (TNFα) and lymphotoxin (TNFβ), specific antibodies were used to identify this cytotoxic factor as TNFα, not lymphotoxin. This production of TNFα was shown to be derived from monocytes, because it disappeared after monocytes were depleted from mononuclear cells. Tumor necrosis factor induced with BCG may be a factor in the anti-tumor effect of topical therapy with BCG. | |||||
出版者 | ||||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
山梨医科大学雑誌 en : 山梨医科大学雑誌 巻 4, 号 4, p. 173-178, 発行日 1989 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |