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<Original Article> Anti-Platelet Action of Gliclazide, an Oral Hypoglycemic Agent, and its Possible Mechanism
https://doi.org/10.34429/00003209
https://doi.org/10.34429/00003209bab63ebd-55e5-4286-b138-45328da4448c
名前 / ファイル | ライセンス | アクション |
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AN10044054_04_02_02.pdf (905.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
タイトル | <Original Article> Anti-Platelet Action of Gliclazide, an Oral Hypoglycemic Agent, and its Possible Mechanism | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Gliclazide | |||||
キーワード | ||||||
主題 | oral hypoglycemic agent | |||||
キーワード | ||||||
主題 | Anti-platelet action | |||||
キーワード | ||||||
主題 | Diabetic complications | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003209 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
Tawata, Masato
× Tawata, Masato× Aida, Kaoru× Shindo, Hideo× Onaya, Toshimasa |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hyperaggregability of platelets observed in diabetic patients has been speculated as one of the causes of chronic diabetic complications. Gliclazide, an oral hypoglycemic agent, inhibited the platelet aggregation, ATP release, the phosphorylation of 40 K dalton protein and a thrombin-induced increase of intraplatelet calcium in vitro. Although a high concentration of gliclazide (500 μg/ml) was required to inhibit the increase of intraplatelet calcium induced by O.1 U/ml thrombin, the inhibitory effect of gliclazide on platelet aggregation induced by 0.5 μg/ml collagen, was observed at a concentration as low as 1 μg/ml. The results of our experiments demonstrated that gliclazide directly inhibits the platelet aggregation at a concentration attainable by the usual oral dose of gliclazide. Therefore, it is likely that gliclazide has a favorable action on diabetic complications, not only by reducing blood glucose level, but also by reducing platelet hyperaggregability. | |||||
出版者 | ||||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
山梨医科大学雑誌 en : 山梨医科大学雑誌 巻 4, 号 2, p. 55-59, 発行日 1989 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |