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<Original Article> The Inhibitory Effect of Iodide on TSH-stimulated Growth of Cultured Rat Thyroid Cells (FRTL-5)
https://doi.org/10.34429/00003219
https://doi.org/10.34429/000032190868f8e8-35b5-4f38-95ee-62e505adf9d6
名前 / ファイル | ライセンス | アクション |
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AN10044054_04_01_03.pdf (837.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
タイトル | <Original Article> The Inhibitory Effect of Iodide on TSH-stimulated Growth of Cultured Rat Thyroid Cells (FRTL-5) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | FRTL-5 | |||||
キーワード | ||||||
主題 | iodide metabolism | |||||
キーワード | ||||||
主題 | thymidine incorporation | |||||
キーワード | ||||||
主題 | thyroid | |||||
キーワード | ||||||
主題 | cAMP | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003219 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
Akasu, Fumito
× Akasu, Fumito× Takazawa, Kazunaga× Endo, Toyoshi× Onaya, Toshimasa |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | We studied the inhibitory effect of iodide on thyroid growth in FRTL-5 cells, which preserve many thyroid functions. When the amount of iodide in medium exceeds 10^-6 M, TSH-stimulated [3H]thymidine incorporation into DNA was significantly inhibited. Methimazole (0.5 mM) reversed the suppression, as was observed in other functions such as thyroid hormone synthesis and secretion. Cell numbers were also monitored to ensure that [3H]thymidine incorporation reflected cell multiplication. Iodide inhibited TSH-stimulated cAMP formation and also 8-bromo-cAMP stimulated-[3H]thymidine incorporation into FRTL-5 cells, indicating that it acts on steps both before and after the formation of cAMP. The data demonstrated an autoregulatory role of iodide on the growth of FRTL-5 cells | |||||
出版者 | ||||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
山梨医科大学雑誌 en : 山梨医科大学雑誌 巻 4, 号 1, p. 21-28, 発行日 1989 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |