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<Original Article> Effects of some Kampo Medicines on Sorbitol Dehydrogenase
https://doi.org/10.34429/00003223
https://doi.org/10.34429/00003223ad10ad13-3b72-4060-a124-358252956280
名前 / ファイル | ライセンス | アクション |
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AN10044054_03_04_02.pdf (468.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
タイトル | <Original Article> Effects of some Kampo Medicines on Sorbitol Dehydrogenase | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | sorbitol dehydrogenase | |||||
キーワード | ||||||
主題 | Aldose reductase | |||||
キーワード | ||||||
主題 | Kampo medicines | |||||
キーワード | ||||||
主題 | polyol pathway | |||||
キーワード | ||||||
主題 | Diabetic complications | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003223 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
Aida, Kaoru
× Aida, Kaoru× Tawata, Masato× Sindo, Hideo× Onaya, Toshimasa |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | We reported previously that some kampo medicines have aldose reductase (AR) inhibiting activities. Then, we studied the effects of these drugs on sorbitol dehydrogenase (SDH) from rat lenses or sheep liver. SDH is another enzyme constituting the polyol pathway. An 0.1 mg/ml concentration of Hatimi-zio-gan slightly stimulated rat lens SDH by 11.7%, and the same concentration of Keihi inhibited it by 34.7%. Keisi-ka-zyutubu-to, Sokei-kakketu-to, Gosya-zinki-gan, Shakuyaku, Kanzo, Sojutsu, Kakobushimatsu, Taiso and shokyo had no etfect on SDH activities. Nevertheles, since these kampo medicines inhibit AR activities, kampo medicines reduce the sorbitol content in tissues by inhibiting AR and not by stimulating SDH. | |||||
出版者 | ||||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
山梨医科大学雑誌 en : 山梨医科大学雑誌 巻 3, 号 4, p. 137-140, 発行日 1988 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |