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然太朗","creatorNameLang":"ja"},{"creatorName":"ヤマガタ, ゼンタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamagata, Zentaro","creatorNameLang":"en"}],"familyNames":[{"familyName":"山縣","familyNameLang":"ja"},{"familyName":"ヤマガタ","familyNameLang":"ja-Kana"},{"familyName":"Yamagata","familyNameLang":"en"}],"givenNames":[{"givenName":"然太朗","givenNameLang":"ja"},{"givenName":"ゼンタロウ","givenNameLang":"ja-Kana"},{"givenName":"Zentaro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"the Yamanashi Adjunct Study of the Japan Environment and Children's Study Group","creatorNameLang":"en"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Previous studies have reported swimming, atopic dermatitis, and filaggrin (FLG) gene mutations as risk factors for molluscum contagiosum (MC) infection. FLG gene mutations impair skin barrier function. The aim of this study was to determine the impact of FLG mutations on the incidence and clinical features of MC. We used data from 2036 children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study, a prospective, birth cohort study. A questionnaire for caregivers (when children were 4 and 8 years of age) asked about clinical features including previous MC incidence and treatment, number of MC lesions at first visit, and time to resolution. Participants underwent genotyping to detect six FLG mutations that are common in the Japanese population. A logistic regression model was used to analyze the association between MC incidence and FLG mutations, adjusted for potential confounders. The cumulative incidence of MC at age 8 years was 47.1%. Among participants with a history of MC, 67.6% had undergone curettage. FLG mutation was a significant risk factor for MC incidence (adjusted odds ratio [aOR] 1.69, 95% confidence interval [CI] 1.18–2.42). Swimming and atopic dermatitis were also significant risk factors for MC. There was no significant association between FLG mutation and the number of MC lesions at the first visit or the time to resolution of lesions. FLG mutation is a risk factor for MC incidence; however, FLG mutations do not affect the number of MC lesions at presentation or the time to resolution.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-01-08"}],"displaytype":"detail","filename":"Journal of Dermatology51_4_484.pdf","filesize":[{"value":"824 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://yamanashi.repo.nii.ac.jp/record/2000395/files/Journal of Dermatology51_4_484.pdf"},"version_id":"27df5ebe-c567-4e1e-bd36-ee4470f454d9"}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30001_publisher9":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons Australia","subitem_publisher_language":"en"},{"subitem_publisher":"Japanese Dermatological Association","subitem_publisher_language":"en"}]},"item_30001_relation14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/1346-8138.17157","subitem_relation_type_select":"DOI"}}]},"item_30001_resource_type11":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30001_rights5":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution 4.0 International (CC BY 4.0)","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"© 2024 The Authors","subitem_rights_language":"en"}]},"item_30001_source_identifier16":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0385-2407","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"1346-8138","subitem_source_identifier_type":"EISSN"}]},"item_30001_subject7":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"atopic dermatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"filaggrin gene mutations","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"molluscum contagiosum","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"time to resolution","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"treatment modalities","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between filaggrin gene mutations and the clinical  features of molluscum contagiosum: The Yamanashi Adjunct  Study of the Japan Environment and Children's Study","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"Association between filaggrin gene mutations and the clinical  features of molluscum contagiosum: The Yamanashi Adjunct  Study of the Japan Environment and Children's Study","item_type_id":"40035","owner":"86","path":["1736319446315"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-01-08"},"publish_date":"2025-01-08","publish_status":"0","recid":"2000395","relation_version_is_last":true,"title":["Association between filaggrin gene mutations and the clinical  features of molluscum contagiosum: The Yamanashi Adjunct  Study of the Japan Environment and Children's Study"],"weko_creator_id":"86","weko_shared_id":-1},"updated":"2025-01-30T03:23:52.625520+00:00"}