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Yamanashi","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"柏木, 賢治","creatorNameLang":"ja"},{"creatorName":"カシワギ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kashiwagi, Kenji","creatorNameLang":"en"}],"familyNames":[{"familyName":"柏木","familyNameLang":"ja"},{"familyName":"カシワギ","familyNameLang":"ja-Kana"},{"familyName":"Kashiwagi","familyNameLang":"en"}],"givenNames":[{"givenName":"賢治","givenNameLang":"ja"},{"givenName":"ケンジ","givenNameLang":"ja-Kana"},{"givenName":"Kenji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30194723","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=30194723"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Purpose: We compared 12-month outcomes of eyes with polypoidal choroidal vasculopathy (PCV) with or without complete regression of polyps observed one month after three monthly intravitreal administrations (loading phase) of aflibercept (2.0 mg/0.05 mL) or brolucizumab (6.0 mg/0.05 mL). Methods: All patients underwent indocyanine green angiography at both baseline and 3 months after initial injection and were followed up monthly with an as-needed regimen for up to 12 months. A total of 62 patients with PCV were included: 30 eyes were treated with brolucizumab, and 32 were treated with aflibercept. Eyes with complete regression of polyps (regression group) had significantly smaller maximum polyp diameter and were more frequently treated with brolucizumab than those without complete regression (non-regression) group. Results: Best corrected visual acuity was comparable between the two groups at 12 months. Although the 12-month retreatment-free proportion was comparable between the two groups (33.0% versus 27.0%, p = 0.59), a retreatment-free period was significantly longer in the regression group than in the non-regression group (8.3 ± 3.3 versus 6.5 ± 3.6 months, p = 0.022), and the number of additional injections was significantly fewer in the regression group than in the non-regression group (1.2 ± 1.2 versus 3.0 ± 2.6, p = 0.007). Conclusions: Complete regression of polyps observed after the initial phase possibly prolongs the retreatment-free period and reduces the number of additional injections irrespective of aflibercept or brolucizumab.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-01-15"}],"displaytype":"detail","filename":"Pharmaceuticals17_6_687.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://yamanashi.repo.nii.ac.jp/record/2000444/files/Pharmaceuticals17_6_687.pdf"},"version_id":"f8ee1846-10d8-4877-8a43-f6f9487d6a0f"}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30001_publisher9":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_30001_relation14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ph17060687","subitem_relation_type_select":"DOI"}}]},"item_30001_resource_type11":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30001_rights5":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution 4.0 International (CC BY 4.0)","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"© 2024 by the authors","subitem_rights_language":"en"}]},"item_30001_source_identifier16":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"1424-8247","subitem_source_identifier_type":"EISSN"}]},"item_30001_subject7":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"polypoidal choroidal vasculopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aflibercept","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"brolucizumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"retreatment-free period","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"number of additional injections","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of Polyp Regression after Loading Phase with 12-Month Outcomes of Eyes with Polypoidal Choroidal Vasculopathy","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"Association of Polyp Regression after Loading Phase with 12-Month Outcomes of Eyes with Polypoidal Choroidal Vasculopathy","item_type_id":"40035","owner":"86","path":["1736904819950"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-01-15"},"publish_date":"2025-01-15","publish_status":"0","recid":"2000444","relation_version_is_last":true,"title":["Association of Polyp Regression after Loading Phase with 12-Month Outcomes of Eyes with Polypoidal Choroidal Vasculopathy"],"weko_creator_id":"86","weko_shared_id":-1},"updated":"2025-01-30T03:30:32.752529+00:00"}