| アイテムタイプ |
デフォルトアイテムタイプ（梨大）(1) |
| 公開日 |
2026-07-01 |
| タイトル |
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|
タイトル |
Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement |
|
言語 |
en |
| 作成者 |
Umed, Tatsuya
Isa, Tadashi
Nishimura, Yukio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Creative Commons Attribution 4.0 International |
|
言語 |
en |
| 権利情報 |
|
|
権利情報 |
© 2022 the Author(s) |
|
言語 |
en |
| 主題 |
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|
言語 |
ja |
|
主題Scheme |
e-Rad_field |
|
主題 |
ライフサイエンス |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
e-Rad_field |
|
主題 |
Life Science |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
Descending motor drive and somatosensory feedback play important roles in modulating muscle activity. Numerous studies have characterized the organization of neuronal connectivity in which descending motor pathways and somatosensory afferents converge on spinal motor neurons as a final common pathway. However, how inputs from these two pathways are integrated into spinal motor neurons to generate muscle activity during actual motor behavior is unknown. Here, we simultaneously recorded activity in the motor cortices (MCx), somatosensory afferent neurons, and forelimb muscles in monkeys performing reaching and grasping movements. We constructed a linear model to explain the instantaneous muscle activity using the activity of MCx (descending input) and peripheral afferents (afferent input). Decomposition of the reconstructed muscle activity into each subcomponent indicated that muscle activity before movement onset could first be explained by descending input from mainly the primary motor cortex and muscle activity after movement onset by both descending and afferent inputs. Descending input had a facilitative effect on all muscles, whereas afferent input had a facilitative or suppressive effect on each muscle. Such antagonistic effects of afferent input can be explained by reciprocal effects of the spinal reflex. These results suggest that descending input contributes to the initiation of limb movement, and this initial movement subsequently affects muscle activity via the spinal reflex in conjunction with the continuous descending input. Thus, spinal motor neurons are subjected to temporally organized modulation by direct activation through the descending pathway and the lagged action of the spinal reflex during voluntary limb movement. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
National Academy of Sciences |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子（シンプル） |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ（シンプル） |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1073/pnas.2208353119 |
|
|
言語 |
en |
|
|
関連名称 |
Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1091-6490 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0027-8424 |
| 書誌情報 |
en : Proceedings of the National Academy of Sciences
巻 119,
号 48,
p. e220835311,
発行日 2022-11-21
|
ProceedingsOfTheNationalAcademyOfSciences119(48)e220835311.pdf (1.6 MB)
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