{"created":"2023-05-18T10:10:58.147161+00:00","id":2653,"links":{},"metadata":{"_buckets":{"deposit":"5155a1e7-820b-4366-b118-e121acaec9fb"},"_deposit":{"created_by":5,"id":"2653","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"2653"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00002653","sets":["205:206:207"]},"author_link":["12834"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"r04","bibliographicPageStart":"r04","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"山梨医科学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Yamanashi medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井原, 達矢","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"12834","nameIdentifierScheme":"WEKO"}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"時計遺伝子は生体内のほぼ全ての細胞に発現し，遺伝子転写を制御する事により生体内の概日リズムを作り出す。時計遺伝子異常による概日リズム障害は，生活習慣病など様々な疾患の原因になっている。尿路でも時計遺伝子の存在は報告され，腎での尿産生リズム・膀胱での蓄尿量変化といった機能を制御していると考えられている。 膀胱上皮は主に外界からのバリアー機能を担うと考えられているが，その他にもPiezo1，TRPV4 といった伸展刺激受容体やConnexin26，VNUT といった神経伝達物質を放出するチャネル類が発現し，蓄尿による膀胱上皮の伸展刺激を感知し尿意を中枢へ伝達する機械センサーとしての機能を有していることが報告されている。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00002646","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨大学医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11839837","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-5091","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_4":{"attribute_name":"タイトルヨミ","attribute_value_mlt":[{"subitem_text_language":"ja-Kana","subitem_text_value":"ヘイセイ　29　ネンド　ワカテ　ケンキュウシャ　ヒョウショウ　ショウガクキン　ジュショウ　キネン　コウエン　ヨウシ　トケイ　イデンシ　イジョウ　ニ　トモナウ　ニョウイ　チカク　ノ　ガイニチ　リズム　ショウガイ　ト　ヤカン　ヒンニョウ　ノ　カンケイ"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"YMJ33-2-r04tor04.pdf","filesize":[{"value":"506.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"YMJ33-2-r04tor04.pdf","objectType":"fulltext","url":"https://yamanashi.repo.nii.ac.jp/record/2653/files/YMJ33-2-r04tor04.pdf"},"version_id":"0d0abc90-d5ed-4da9-a4fa-06f8fb41cca1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<平成29年度若手研究者表彰奨学金受賞記念講演要旨>時計遺伝子異常に伴う尿意知覚の概日リズム障害と夜間頻尿の関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<平成29年度若手研究者表彰奨学金受賞記念講演要旨>時計遺伝子異常に伴う尿意知覚の概日リズム障害と夜間頻尿の関係","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["207"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-15"},"publish_date":"2019-03-15","publish_status":"0","recid":"2653","relation_version_is_last":true,"title":["<平成29年度若手研究者表彰奨学金受賞記念講演要旨>時計遺伝子異常に伴う尿意知覚の概日リズム障害と夜間頻尿の関係"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-10-11T07:17:02.110015+00:00"}