{"created":"2023-05-18T10:10:58.839820+00:00","id":2669,"links":{},"metadata":{"_buckets":{"deposit":"8ccc7645-63c2-41b4-9507-e461ae2edf23"},"_deposit":{"created_by":5,"id":"2669","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"2669"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00002669","sets":["205:206:209"]},"author_link":["12871","12872","12873"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"63","bibliographicPageStart":"53","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"山梨医科学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Yamanashi medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"笠井, 慎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"12871","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古市, 嘉行","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"12872","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"杉田, 完爾","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"12873","nameIdentifierScheme":"WEKO"}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"炎症性細胞や癌細胞はCD44 を高発現していることが知られている。一方細胞外マトリッ クス（extracellular matrix, ECM）や間葉系細胞はCD44 の主要なリガンドであるhyaluronan （hyaluronic acid, HA）を多量に有しているため，CD44-HA 相互作用の場として，炎症や癌細 胞の生存・増殖に重要な役割を果たしている。最近の研究によりHA の機能はポリマー鎖の長 さ（molecular size）により異なることが明らかとなってきたが，我々はCD44 を高発現している B-precursor acute lymphoblastic leukemia（ALL）細胞株を炎症メディエーターである超低分子量 HA（ultra-low-molecular-weight HA, ULMW-HA）を用いて刺激すると細胞死が誘導されること を見出した。この細胞死はROS の細胞内蓄積とHMGB1 の細胞外放出を伴うネクローシスが主体 であった。炎症時におけるCD44-HA 相互作用の詳細な機能や，CD44 高発現腫瘍細胞の生物学的 特性についての理解が深まることにより，CD44 を標的とした悪性腫瘍の新たな治療が可能になる かもしれない。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00002662","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨大学医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11839837","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-5091","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_4":{"attribute_name":"タイトルヨミ","attribute_value_mlt":[{"subitem_text_language":"ja-Kana","subitem_text_value":"ソウセツ CD44 コウハツゲン シュヨウ ト エンショウ メディエーター"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"YMJ32-2-053to063.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"YMJ32-2-053to063.pdf","objectType":"fulltext","url":"https://yamanashi.repo.nii.ac.jp/record/2669/files/YMJ32-2-053to063.pdf"},"version_id":"61c27c9d-89a7-4013-889e-c935b9ae0940"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD44","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症メディエーター","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory mediator","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hyaluronan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外マトリックス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ECM","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reactive oxygen species","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ROS","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>CD44 高発現腫瘍と炎症メディエーター","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>CD44 高発現腫瘍と炎症メディエーター","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["209"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-30"},"publish_date":"2018-01-30","publish_status":"0","recid":"2669","relation_version_is_last":true,"title":["<総説>CD44 高発現腫瘍と炎症メディエーター"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-10-11T07:17:34.715306+00:00"}