{"created":"2023-05-18T10:10:59.872650+00:00","id":2687,"links":{},"metadata":{"_buckets":{"deposit":"731d4a1c-b165-493d-b243-126cb0395dfe"},"_deposit":{"created_by":5,"id":"2687","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"2687"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00002687","sets":["205:206:210"]},"author_link":["12928"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"52","bibliographicPageStart":"45","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"山梨医科学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Yamanashi medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高野, 勝弘","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"血栓症や出血の原因が血液そのものにある場合，それぞれ血栓性素因，出血傾向と呼ばれる。本稿では，血栓性素因と出血傾向の診療の進め方を，自験例での患者データをもとに論じた。Case 1：上腸間膜静脈血栓症を起こした 51歳，男性。血栓性素因の検索を行い，先天性血栓性素因の原因の一つである凝固系調節因子Protein Sの活性がProtein C活性の半分以下に減少しており，またProtein Sの抗原量に比し活性が明らかに低いことが判明した。以上より本例は，先天性Protein S分子異常症と考えられた。Case 2：CKD，透析導入となった79歳，男性。透析時の穿刺後の止血困難が見られた。出血傾向の原因検索を行ったところ凝固第V 因子（FV）が高度に低下しており，交差混合試験（cross-mixing test）では非典型的ではあったがインヒビター・パターン，FV のBethesda 法アッセイで1.4 BU/mL のFVインヒビターを検出した。以上より本例は，まれな後天性FVインヒビターと診断された。また凝固系インヒビターであるループスアンチコアグラントも陽性であり，FVインヒビターとの関連を検索中である。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00002680","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨大学医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11839837","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-5091","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_4":{"attribute_name":"タイトルヨミ","attribute_value_mlt":[{"subitem_text_language":"ja-Kana","subitem_text_value":"ショウレイホウコク ケッセンセイ ソイン シュッケツ ケイコウ ノ シンリョウ ノ ススメカタ : ケッセンショウ シュッケツ ケイコウ ノ ケース レポート オ ツウジテ"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"YMJ32-1-045to052.pdf","filesize":[{"value":"768.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"YMJ32-1-045to052.pdf","objectType":"fulltext","url":"https://yamanashi.repo.nii.ac.jp/record/2687/files/YMJ32-1-045to052.pdf"},"version_id":"19bd611e-9f93-4d92-acc5-c5866765f6fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血栓性素因","subitem_subject_language":"ja"},{"subitem_subject":"Protein S","subitem_subject_language":"en"},{"subitem_subject":"出血傾向","subitem_subject_language":"ja"},{"subitem_subject":"インヒビター","subitem_subject_language":"ja"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<症例報告>血栓性素因・出血傾向の診療の進め方 : 血栓症・出血傾向のケースレポートを通じて","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<症例報告>血栓性素因・出血傾向の診療の進め方 : 血栓症・出血傾向のケースレポートを通じて","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["210"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-07-11"},"publish_date":"2017-07-11","publish_status":"0","recid":"2687","relation_version_is_last":true,"title":["<症例報告>血栓性素因・出血傾向の診療の進め方 : 血栓症・出血傾向のケースレポートを通じて"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-10-11T07:18:09.368902+00:00"}