@article{oai:yamanashi.repo.nii.ac.jp:00003046,
 author = {OHTA, Emiko and ENDO, Toyoshi and OHMORl, Masayuki and OHNO, Makoto and ONAYA, Toshimasa},
 issue = {4},
 journal = {山梨医科大学雑誌, Yamanashi medical journal},
 month = {},
 note = {The relationship between the specificities of rat thyrotropin receptor antibodies and their biological effects on the rat thyroid in vivo was studied. Sixteen male Wistar rats were immunized with one of two synthetic peptides; one corresponding to the N-terminal region, amino acid residues 29-57, termed RAT-N, and the other corresponding to the C-terminal region of the extracellular domain, amino acid residues 341-370, termed RAT-P. Rats immunized with RAT-N possessed thyroidstimulating antibody (TSAb) activity and significantly higher serum concentrations of 3, 5, 3'-tri-iodothyronine (T3) than those of the control groups. In contrast, antibodies generated in rats immunized with RAT-P posscssed TSH-binding inhibitor immunoglobulin (TBII) activity and lower T3, levels than those in the control group. Histologically, there were no inflammatory or destructive reactions in the thyroid glands of any of the rats. These findings suggest that thyrotropin receptor antibodies against the N-terminus have stimulatory effects on thyrocytes, and that antibodies generated against the C-terminal region of the extracellular domain play an inhibitory role in thyroid function in vivo.},
 pages = {143--150},
 title = {<Original Article> Immunization with Rat Thyrotropin Receptor Peptides Corresponding to Two Specific Extracellular Domains Alters Thyroid Function in vivo},
 volume = {12},
 year = {1997}
}