{"created":"2023-05-18T10:11:22.454145+00:00","id":3114,"links":{},"metadata":{"_buckets":{"deposit":"8db37e29-dabf-411b-87b3-1e24555ae677"},"_deposit":{"created_by":1,"id":"3114","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3114"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003114","sets":["205:251:287"]},"author_link":["14466","14465","14467","14462","14463","14464"],"item_10001_alternative_title_1":{"attribute_name":"タイトル(別表記)","attribute_value_mlt":[{"subitem_alternative_title":"Promoting Effects of Testosterone on Prostatic Carcinogenesis in Castrated F344 Rats"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"35","bibliographicPageStart":"27","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌"},{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白須, 宣彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小松, 秀樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"上野, 精"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"F344系雄性ラットを用いて,プロモーション期にある前立腺に対して testosteroneの投与が前立腺癌の発生,進展に及ほす影響を検討した。11週齢で全ラットを去勢し,これをA～Dの4群に分けた。去勢後3週間でA群,B群は testosterone propionate (TP) 25mg (平均体重227.5±21g)を3日間連続皮下投与して前立腺上皮の増殖を促し,1日おいてN-methyl-N-nitrosourea (MNU) 10mgを静脈内に投与した。さらにA群はMNU投与2日後より56週にわたり testosterone enanthate (TE) 12.5 mgを4週間に1度皮下に投与した。C群はTPおよびMNUは投与せず,A群と同期間TEを投与した。D群は去勢のみとした。60週で全群屠殺解剖し,病理組織学的に比較検討した。付属生殖器癌はA群では26匹中4匹(15%):前立腺癌3匹,精癌1匹に認めた。しかし,他の3群には付属生殖器癌は認めなかった。付属生殖器増殖性病変(癌+過形成)はA群では7/26(27%),C群では1/8(12%)に認めたが,B群,D群ではそれぞれ24匹,9匹のいずれにも認めなかった(A群,B群間にp<0.05で有意差あり)。プロモーション期のTE投与は付属生殖器増殖性病変に促進的に働くと思われた。またA,B両群には皮膚扁平上皮癌をそれぞれ16/26(62%),13/24(54%)にさらに小腸の腺癌をそれぞれ8/26(31%),4/24 (17%)に認めた。","subitem_description_type":"Other"}]},"item_10001_full_name_24":{"attribute_name":"著者名(別表記)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14465","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shirasu, Nobuhiko"}]},{"nameIdentifiers":[{"nameIdentifier":"14466","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Komatu, Hideki"}]},{"nameIdentifiers":[{"nameIdentifier":"14467","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ueno, Akira"}]}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003107","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_4":{"attribute_name":"タイトルヨミ","attribute_value_mlt":[{"subitem_text_value":"ゲンチョ キョセイ ラット オ モチイタ ゼンリツセン ハツガン ニオケル テストステロン ノ プロモーション サヨウ ノ ケントウ"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_09_01_04.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_09_01_04.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3114/files/AN10044054_09_01_04.pdf"},"version_id":"b341b911-8758-484f-be3b-65d9c2239a68"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ラットの前立腺癌"},{"subitem_subject":"メチルニトロソウレア"},{"subitem_subject":"テストステロン"},{"subitem_subject":"Prostatic cancer of rats"},{"subitem_subject":"N-metyl-N-nitrosourea"},{"subitem_subject":"Testosterone"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<原著>去勢ラットを用いた前立腺発癌におけるテストステロンのプロモーション作用の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<原著>去勢ラットを用いた前立腺発癌におけるテストステロンのプロモーション作用の検討"}]},"item_type_id":"10001","owner":"1","path":["287"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-05-18"},"publish_date":"2010-05-18","publish_status":"0","recid":"3114","relation_version_is_last":true,"title":["<原著>去勢ラットを用いた前立腺発癌におけるテストステロンのプロモーション作用の検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-10-11T07:38:04.593514+00:00"}