{"created":"2023-05-18T10:11:24.735029+00:00","id":3149,"links":{},"metadata":{"_buckets":{"deposit":"a8cad365-ba57-4d65-b647-69d46e79bbec"},"_deposit":{"created_by":1,"id":"3149","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3149"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003149","sets":["205:251:294"]},"author_link":["14678","14679"],"control_number":"3149","item_10001_alternative_title_1":{"attribute_name":"タイトル(別表記)","attribute_value_mlt":[{"subitem_alternative_title":"Early Influence of Intraarterial Administration of Cisplatin-Lipiodol Suspension (CLS) on the Liver and Kidneys","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"78","bibliographicPageStart":"67","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Yamanashi medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"日原, 敏彦","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"14678","nameIdentifierScheme":"WEKO"}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"Cisplatin-Lipiodol suspension (CLS)の固有肝動脈内動注後の早期の影響をしらべる目的で,四塩化炭素により作製した肝硬変ウサギおよび正常ウサギあわせて28羽に対してCLS(n=6),Cisplatin(CDDP)単独(n=6),Lipiodol単独(n=6),生理食塩水(n=8)をそれぞれ投与した。2羽は組織学的対照として用いた。処置後のCDDPの体内動態を検討するため,血清中および切除した肝臓と腎臓の白金濃度を測定した。肝臓および腎臓の組織学的変化とGOT,GPT,BUN,血中クレアチニンの経時的変化を調べた。CLSを投与した肝硬変ウサギではGOT,GPTが高値(P<0.01)を示した。CDDPを投与した正常ウサギではBUN,血中クレアチニンが高値(P<0.01)を示した。組織学的にはCLSを投与した肝硬変ウサギで肝細胞変性と炎症浸潤が顕著であった。CDDPを投与した正常ウサギの腎臓で近位尿細管の変性と壊死が顕著であった。白金濃度の値は早期の肝臓と腎臓の障害の程度と関連性を示した。結論として,CLS動注後早期に肝硬変ウサギで肝障害が重度(腎障害は軽度)になる傾向にあった。CLSを肝硬変に伴う肝悪性腫瘍に用いる際に注意が必要であることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_full_name_24":{"attribute_name":"著者名(別表記)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14679","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hihara, Toshihiko","nameLang":"en"}]}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003142","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_07_02_05.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_07_02_05.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3149/files/AN10044054_07_02_05.pdf"},"version_id":"1ac2a448-5184-4f3d-a2e2-b1825b0ae6d8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"シスプラチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"リピオドール懸濁液","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈内投与","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"副作用","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"肝臓","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腎臓","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Cisplatin-Liipiodol suspension (CLS)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intraarterial administration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Side-reaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kedneys","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<原著>肝悪性腫瘍動注療法に用いる Cisplatin-Lipiodol suspensionの肝臓,腎臓への影響に関する実験的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<原著>肝悪性腫瘍動注療法に用いる Cisplatin-Lipiodol suspensionの肝臓,腎臓への影響に関する実験的研究","subitem_title_language":"ja"},{"subitem_title":"ゲンチョ カンアクセイ シュヨウ ドウチュウ リョウホウ ニ モチイル Cisplatin-Lipiodol suspe ノ カンゾウ ジンゾウ ヘノ エイキョウ ニ カンスル ジッケンテキ ケンキュウ","subitem_title_language":"ja-Kana"}]},"item_type_id":"10001","owner":"1","path":["294"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-05-18"},"publish_date":"2010-05-18","publish_status":"0","recid":"3149","relation_version_is_last":true,"title":["<原著>肝悪性腫瘍動注療法に用いる Cisplatin-Lipiodol suspensionの肝臓,腎臓への影響に関する実験的研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2024-11-26T02:27:02.479099+00:00"}