@article{oai:yamanashi.repo.nii.ac.jp:00003155,
 author = {KOBAYASHI, Isao and HAMAOKA, Satomi and AMEMIYA, Norihiko and ENDO, Takeshi and TAMURA, Kohji and KUME, Shoji and AKABANE, Kenji and SUZUKI, Hiroshi},
 issue = {4},
 journal = {山梨医科大学雑誌, 山梨医科大学雑誌},
 month = {},
 note = {Protein S functional activity, free and total protein S antigen as well as C4b binding protein antigen were assayed in patients with liver cirrhosis and the amounts of free protein S and protein S bound to C4b binding protbin in normal subjects and in patients with liver cirrhosis were also calculated from the area of two-dimensional immunoelectrophoresis. Cholinesterase activity correlated well with total protein S, C4b binding protein and protein S bound to C4b binding protein but not with the functional activity of protein S nor with free protein S antigen. The ratio of free protein S to protein S bound to C4b binding protein was 68±3%; in normal subjects and 127±69% in patients with liver cirrhosis. C4b binding protein had an inverse correlation with the ratio of free protein S to protein S bound to C4b binding protein. From these data, we can conclude that protein S bound to C4b binding protein but not free protein S reflects the level of liver function of macromolecular synthesis in liver cirrhosis and that the binding condition between C4b binding protein and protein S in patients with liver cirrhosis is different from that in normal subjects.},
 pages = {183--191},
 title = {<Original Article> Assessment of Plasma Protein S Functional Activity and Antigen in Patients with Liver Cirrhosis},
 volume = {6},
 year = {1991}
}