{"created":"2023-05-18T10:11:25.120757+00:00","id":3155,"links":{},"metadata":{"_buckets":{"deposit":"8d4cbddb-933f-4b78-8a11-6498159973c3"},"_deposit":{"created_by":1,"id":"3155","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3155"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003155","sets":["205:251:296"]},"author_link":["14708","14710","14713","14712","14711","14714","14715","14709"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"191","bibliographicPageStart":"183","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌"},{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KOBAYASHI, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAMAOKA, Satomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"AMEMIYA, Norihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ENDO, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAMURA, Kohji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUME, Shoji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"AKABANE, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUZUKI, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"Protein S functional activity, free and total protein S antigen as well as C4b binding protein antigen were assayed in patients with liver cirrhosis and the amounts of free protein S and protein S bound to C4b binding protbin in normal subjects and in patients with liver cirrhosis were also calculated from the area of two-dimensional immunoelectrophoresis. Cholinesterase activity correlated well with total protein S, C4b binding protein and protein S bound to C4b binding protein but not with the functional activity of protein S nor with free protein S antigen. The ratio of free protein S to protein S bound to C4b binding protein was 68±3%; in normal subjects and 127±69% in patients with liver cirrhosis. C4b binding protein had an inverse correlation with the ratio of free protein S to protein S bound to C4b binding protein. From these data, we can conclude that protein S bound to C4b binding protein but not free protein S reflects the level of liver function of macromolecular synthesis in liver cirrhosis and that the binding condition between C4b binding protein and protein S in patients with liver cirrhosis is different from that in normal subjects.","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003148","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_06_04_03.pdf","filesize":[{"value":"805.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_06_04_03.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3155/files/AN10044054_06_04_03.pdf"},"version_id":"630ae098-de5a-461a-bece-1e5ca222d64c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Protein S functional activity"},{"subitem_subject":"Total and free protein S antigen"},{"subitem_subject":"Protein S bound to C4b binding protein"},{"subitem_subject":"C4b binding protein"},{"subitem_subject":"Liver cirrhosis"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Original Article> Assessment of Plasma Protein S Functional Activity and Antigen in Patients with Liver Cirrhosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Original Article> Assessment of Plasma Protein S Functional Activity and Antigen in Patients with Liver Cirrhosis"}]},"item_type_id":"10001","owner":"1","path":["296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-05-18"},"publish_date":"2010-05-18","publish_status":"0","recid":"3155","relation_version_is_last":true,"title":["<Original Article> Assessment of Plasma Protein S Functional Activity and Antigen in Patients with Liver Cirrhosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-10-11T07:40:01.488228+00:00"}