{"created":"2023-05-18T10:11:25.310007+00:00","id":3158,"links":{},"metadata":{"_buckets":{"deposit":"a0a86521-df87-478d-99cc-b08f52455926"},"_deposit":{"created_by":1,"id":"3158","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3158"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003158","sets":["205:251:297"]},"author_link":["14744","14745","14743"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"135","bibliographicPageStart":"127","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌"},{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KANEKO, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ENDOH, Kazushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SATO, Akio"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"A physiological pharmacokinetic model of the transfer of organic solvents in the human body was developed. The model was comprised of seven compartments, i.e., lungs, vessel-rich tissues, vessel-poor tissues, muscles, fat tissues, gastrointestinal tissues, and liver, each being connected to the others by blood flow. The transfer of organic solvents was expressed by simultanfous differential equations, which were then solved numerically by a personal computer using a slmple spreadsheet program. m-Xylene was used as the representative organic solvent. Partition coefficients of m-xylene between blood and air and between body tissue and blood were experimentally determined with blood and tissues of rats. The metabolic constants (Vmax and Km) of m-xylene metabolism and the excretion rate constant of m-methyl hippuric acid (m-MHA) were also determined using rats. These animal data were scaled up and used as the simulation parameters for humans. The results of the simulation of human exposure to m-xylene were essentially in agreement with human experimental data.","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003151","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_06_03_01.pdf","filesize":[{"value":"804.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_06_03_01.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3158/files/AN10044054_06_03_01.pdf"},"version_id":"ee72f95d-ecf4-4ac2-b2b2-f4f3c1f847dc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Physiologically based pharmacokinetic model"},{"subitem_subject":"m-Xylene"},{"subitem_subject":"m-Methyl hippuric acid"},{"subitem_subject":"Michaelis-Menten type metabolism"},{"subitem_subject":"Animal scale-up"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Original Article> Biological Monitoring of Exposure to Organic Solvent Vapors I. A Physiological Simulation Model of m-Xylene Pharmacokinetics in Man","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Original Article> Biological Monitoring of Exposure to Organic Solvent Vapors I. A Physiological Simulation Model of m-Xylene Pharmacokinetics in Man"}]},"item_type_id":"10001","owner":"1","path":["297"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-05-18"},"publish_date":"2010-05-18","publish_status":"0","recid":"3158","relation_version_is_last":true,"title":["<Original Article> Biological Monitoring of Exposure to Organic Solvent Vapors I. A Physiological Simulation Model of m-Xylene Pharmacokinetics in Man"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-10-11T07:40:20.322292+00:00"}