@article{oai:yamanashi.repo.nii.ac.jp:00003190, author = {OZAKI, Yukio and OYAMA, Toshio and MATSUMOTO, Yuki and KUME, Shoji}, issue = {2}, journal = {山梨医科大学雑誌, 山梨医科大学雑誌}, month = {}, note = {Of the five cytokines tested (tumor necrosis factor, interleukin 1, colony-stimulating factor, interferon alpha, beta, and gamma), only tumor necrosis factor (TNF) showed a potent stimulatory effect on acetyltransferase activity of human neutrophils. Acetyltransforase is a key enzyme for the production of platelet-activating factor. This potentiating effect of TNF was time- and dose-dependent and was effectively blocked by TNF antiserum. Intracellular Ca++ elevation, protein kinase C activation, and arachidonic acid metabolites appeared not to be involved in the TNF-induced potentiation of the acetyltransferase activity in neutrophils.}, pages = {97--103}, title = { Tumor Necrosis Factor Stimulates Acetyltransferase Activity of Human Neutrophils}, volume = {5}, year = {1990} }