{"created":"2023-05-18T10:11:27.349500+00:00","id":3199,"links":{},"metadata":{"_buckets":{"deposit":"de4a4043-ab3f-476c-a713-b69235bf22a9"},"_deposit":{"created_by":1,"id":"3199","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3199"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003199","sets":["205:251:303"]},"author_link":["15033","15038","15032","15031","15036","15035","15034","15037"],"item_10001_alternative_title_1":{"attribute_name":"タイトル(別表記)","attribute_value_mlt":[{"subitem_alternative_title":"Histological Structures of the Peripheral Autonomic Innervation Apparatus.2. A Historical Evaluation of the \"\"Interstitial Cells of Cajal.\"\""}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"61","bibliographicPageStart":"51","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌"},{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"笹本, 真理子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"木村, 久美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小林, 繁"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"塚原, 重雄"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"モルモットの虹彩,毛様体,毛様体神経節,上頸神経節,膵臓,小腸,副腎髄質などの自律神経系の組織学的構造を,Champy-Maillet法による光学顕微鏡的手法,走査/透過型電子顕微鏡法,免疫組織化学的手法を用いて検討した。すべての器官について,末梢自律神経系の終末装置は,Hillarp (1946,1959)が提唱した自律神経基礎網(autonomic groundplexus)をなしていた。すなわち,S-10Ob蛋白質の免疫活性を含む膠細胞が並んで網目状の「骨格」を形成し,神経ペプタイド(P物質を免疫染色した)を含む神経突起の束が,それにおおわれて走る。神経突起の束は,膠細胞の骨格に沿って分離・合体を繰り返し,網目状構造を作るが,個々の線維は独立していて吻合しない。Cajal (1889,1893,1911)によって記載された「間質細胞(interstitial cells)」の本体について検討した。著者らは,若いCajal (1889,1893)は,自律神経基礎網のSchwann細胞と神経突起が,Golgi法で同時に染まった複合体を,特殊なニューロンとして誤って解釈してたと結論づけた。そして,「Cajalの間質細胞」をめぐって1889年以来の100年間に,提出された主な学説を,医学史的に批評した。現代の研究者がinterstitial cells of Cajalを一種の線維芽細胞と考えてしまった原因のひとつとして, Cajal (1911)が,晩年にメチレン青法を使って染めた腸の筋層の線維芽細胞を,若い頃にGolgi法でみた「間質細胞」と混同したことがあげられる。","subitem_description_type":"Other"}]},"item_10001_full_name_24":{"attribute_name":"著者名(別表記)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"15035","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sasamoto, Mariko"}]},{"nameIdentifiers":[{"nameIdentifier":"15036","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kimura, Kumiko"}]},{"nameIdentifiers":[{"nameIdentifier":"15037","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kobayashi, Shigeru"}]},{"nameIdentifiers":[{"nameIdentifier":"15038","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsukahara, Shigeo"}]}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003192","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_4":{"attribute_name":"タイトルヨミ","attribute_value_mlt":[{"subitem_text_value":"ゲンチョ マッショウ ジリツ シンケイ ノ シュウマツ ソウチ ノ ソシキガクテキ コウゾウ 2 サイキン ノ ケイタイガクテキ ケンキュウ ニ モトズク CAJAL ノ カンシツ サイボウ ノ ホンタイ ニツイテ ノ イガクシテキ コウサツ"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_05_01_06.pdf","filesize":[{"value":"4.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_05_01_06.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3199/files/AN10044054_05_01_06.pdf"},"version_id":"39d96873-e815-4fcc-a997-66ffdd6c8162"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カハールの間質細胞"},{"subitem_subject":"自律神経基礎網"},{"subitem_subject":"線維芽様細胞"},{"subitem_subject":"末梢神経支配"},{"subitem_subject":"膠細胞による骨格"},{"subitem_subject":"interstitial cells of Cajal"},{"subitem_subject":"autonomic groundplexus"},{"subitem_subject":"fibroblast-like cells"},{"subitem_subject":"peripheral innervation"},{"subitem_subject":"glial framework"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<原著>末梢自律神経の終末装置の組織学的構造 2.最近の形態学的研究に基ずく「Cajalの間質細胞」の本体についての医学史的考察","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<原著>末梢自律神経の終末装置の組織学的構造 2.最近の形態学的研究に基ずく「Cajalの間質細胞」の本体についての医学史的考察"}]},"item_type_id":"10001","owner":"1","path":["303"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-05-18"},"publish_date":"2010-05-18","publish_status":"0","recid":"3199","relation_version_is_last":true,"title":["<原著>末梢自律神経の終末装置の組織学的構造 2.最近の形態学的研究に基ずく「Cajalの間質細胞」の本体についての医学史的考察"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-10-11T07:41:41.945877+00:00"}