{"created":"2023-05-18T10:11:27.796422+00:00","id":3206,"links":{},"metadata":{"_buckets":{"deposit":"27b84832-0a7a-41d7-aeb7-2e686709c771"},"_deposit":{"created_by":1,"id":"3206","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3206"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003206","sets":["205:251:304"]},"author_link":["15078","15077","15076","15079"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"178","bibliographicPageStart":"173","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌"},{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YABUSAKI, Noboru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOMATSU, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UENO, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TASAKA, Kachio"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"Healthy human peripheral mononuclear cells cultured with bacillus Calmette-Guerin (BCG) alone produced cytotoxic factor that lysed L.P3 murine fibroblast cells after 2 hours of culture, and the production reached a peak after 24 to 48 hours. Since L.P3 cells are sensitive both to tumor necrosis factor (TNFα) and lymphotoxin (TNFβ), specific antibodies were used to identify this cytotoxic factor as TNFα, not lymphotoxin. This production of TNFα was shown to be derived from monocytes, because it disappeared after monocytes were depleted from mononuclear cells. Tumor necrosis factor induced with BCG may be a factor in the anti-tumor effect of topical therapy with BCG.","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003199","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_04_04_03.pdf","filesize":[{"value":"634.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_04_04_03.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3206/files/AN10044054_04_04_03.pdf"},"version_id":"ca4ea494-ebe4-4326-a918-407ad8d0f5bd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"tumor necrosis factor"},{"subitem_subject":"Bacillus Calmette-Guerin"},{"subitem_subject":"human monocytes"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Original Article> In vitro Production of Tumor Necrosis Factor (TNFα/Cachectin) from Human Peripheral Blood Monocytes Stimulated with Bacillus Calmette-Guerin. - A Possible Mechanism of BCG Therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Original Article> In vitro Production of Tumor Necrosis Factor (TNFα/Cachectin) from Human Peripheral Blood Monocytes Stimulated with Bacillus Calmette-Guerin. - A Possible Mechanism of BCG Therapy"}]},"item_type_id":"10001","owner":"1","path":["304"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-05-18"},"publish_date":"2010-05-18","publish_status":"0","recid":"3206","relation_version_is_last":true,"title":["<Original Article> In vitro Production of Tumor Necrosis Factor (TNFα/Cachectin) from Human Peripheral Blood Monocytes Stimulated with Bacillus Calmette-Guerin. - A Possible Mechanism of BCG Therapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-10-11T07:42:00.147535+00:00"}