{"created":"2023-05-18T10:11:29.131177+00:00","id":3230,"links":{},"metadata":{"_buckets":{"deposit":"9b09ac99-2c32-4a09-9656-5663fb22c7ef"},"_deposit":{"created_by":1,"id":"3230","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3230"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003230","sets":["205:251:308"]},"author_link":["15257","15256","15254","15255"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"140","bibliographicPageStart":"137","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌"},{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Aida, Kaoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tawata, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sindo, Hideo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onaya, Toshimasa"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"We reported previously that some kampo medicines have aldose reductase (AR) inhibiting activities. Then, we studied the effects of these drugs on sorbitol dehydrogenase (SDH) from rat lenses or sheep liver. SDH is another enzyme constituting the polyol pathway. An 0.1 mg/ml concentration of Hatimi-zio-gan slightly stimulated rat lens SDH by 11.7%, and the same concentration of Keihi inhibited it by 34.7%. Keisi-ka-zyutubu-to, Sokei-kakketu-to, Gosya-zinki-gan, Shakuyaku, Kanzo, Sojutsu, Kakobushimatsu, Taiso and shokyo had no etfect on SDH activities. Nevertheles, since these kampo medicines inhibit AR activities, kampo medicines reduce the sorbitol content in tissues by inhibiting AR and not by stimulating SDH.","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003223","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_03_04_02.pdf","filesize":[{"value":"468.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_03_04_02.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3230/files/AN10044054_03_04_02.pdf"},"version_id":"aa786a98-2f8b-4611-8825-f078ab6986b5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"sorbitol dehydrogenase"},{"subitem_subject":"Aldose reductase"},{"subitem_subject":"Kampo medicines"},{"subitem_subject":"polyol pathway"},{"subitem_subject":"Diabetic complications"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Original Article> Effects of some Kampo Medicines on Sorbitol Dehydrogenase","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Original Article> Effects of some Kampo Medicines on Sorbitol Dehydrogenase"}]},"item_type_id":"10001","owner":"1","path":["308"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-05-18"},"publish_date":"2010-05-18","publish_status":"0","recid":"3230","relation_version_is_last":true,"title":["<Original Article> Effects of some Kampo Medicines on Sorbitol Dehydrogenase"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-10-11T07:42:59.618006+00:00"}