{"created":"2023-05-18T10:11:29.652645+00:00","id":3242,"links":{},"metadata":{"_buckets":{"deposit":"4379ef92-8632-46ec-8d09-080de1b3e8dd"},"_deposit":{"created_by":1,"id":"3242","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3242"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003242","sets":["205:251:310"]},"author_link":["15354","15352","15353","15351","15355"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"56","bibliographicPageStart":"47","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌"},{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Aida, Kaoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tawata, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shindo, Hideo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukahara, Shigeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onaya, Toshimasa"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"Anti-inflammatory drugs and ONO-2235 were tested for their ability to inhibit lens aldose reductase and sorbitol accumulation in red blood cells. Sulindac, an anti-inflammatory drug, and ONO-2235 were shown to be potent inhibitors of aldose reductases from human cataractous lenses, bovine lenses and rat lenses. ONO-2235 was the most potent inhibitor with IC50 of 2×10^-8 M, using human lens aldose reductase. Sulindac and ONO-2235 also inhibited the accumulation of sorbitol in human red blood cells. The IC50s were 6.2×10^-6 M, and 6×10^-6 M, respectively. Similarly, indomethacin and its prodrug, acemetacine, inhibited both aldose reductase in rat lens and sorbitol accumulation in human red blood cells. Furthermore, in diabetic rats, sulindac significantly suppressed sorbitol accumulation in red blood cells and sciatic nerves. These results suggest that sulindac as well as ONO-2235 can be useful in preventing chronic diabetic complications.","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003235","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_03_02_02.pdf","filesize":[{"value":"909.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_03_02_02.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3242/files/AN10044054_03_02_02.pdf"},"version_id":"8b1db000-9bae-432c-aea1-db0dd84e9baf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anti-inflammatory drug"},{"subitem_subject":"ONO-2235"},{"subitem_subject":"Aldose reductase"},{"subitem_subject":"sorbitol"},{"subitem_subject":"Diabetes mellitus"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Original Article> Effects of anti-inflammatory drugs and ONO-2235 on lens aldose reductase and on sorbitol accumulation in red blood cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Original Article> Effects of anti-inflammatory drugs and ONO-2235 on lens aldose reductase and on sorbitol accumulation in red blood cells"}]},"item_type_id":"10001","owner":"1","path":["310"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-05-18"},"publish_date":"2010-05-18","publish_status":"0","recid":"3242","relation_version_is_last":true,"title":["<Original Article> Effects of anti-inflammatory drugs and ONO-2235 on lens aldose reductase and on sorbitol accumulation in red blood cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-10-11T07:43:27.098781+00:00"}