{"created":"2023-05-18T10:11:30.601228+00:00","id":3264,"links":{},"metadata":{"_buckets":{"deposit":"796e0143-b040-4be9-92b1-12eb14f75744"},"_deposit":{"created_by":1,"id":"3264","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3264"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003264","sets":["205:251:314"]},"author_link":["15507","15503","15502","15501","15504","15500","15505","15506"],"item_10001_alternative_title_1":{"attribute_name":"タイトル(別表記)","attribute_value_mlt":[{"subitem_alternative_title":"A Pharmacokinetic Study of Adriamycin after Intraportal Injection"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"72","bibliographicPageStart":"69","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌"},{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梅北, 信孝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩崎, 甫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中込, 博"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"上野, 明"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"肝転移予防に対する抗癌剤門脈内注入療法の基礎的検討としてadriamycin (以下ADR) の門脈投与時の薬物動態を検討した。家兎をもちい0.4mg/kgのADRの門脈内注入群(A群)と末梢静脈注入群(B群)につき投与後20分迄のADR血中濃度と肝,腎,心のADR組織内濃度を測定した。血中濃度はtwo compartment open modelにより解析した。血中初期濃度はA群でB群の67%であり,血中濃度時間曲面下面積より求めた肝におけるADRの初回通過効果は約21%であった。肝組織内濃度はA群はB群の約3倍と有意に高く,逆に心および腎組織内濃度はB群で有意に高かった。以上よりADRの門脈内注入法は肝を標的臓器とした場合有効な投与方法と考えられた。","subitem_description_type":"Other"}]},"item_10001_full_name_24":{"attribute_name":"著者名(別表記)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"15504","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Umekita, Nobutaka"}]},{"nameIdentifiers":[{"nameIdentifier":"15505","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Iwasaki, Masaru"}]},{"nameIdentifiers":[{"nameIdentifier":"15506","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakagomi, Hiroshi"}]},{"nameIdentifiers":[{"nameIdentifier":"15507","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ueno, Akira"}]}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003257","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_4":{"attribute_name":"タイトルヨミ","attribute_value_mlt":[{"subitem_text_value":"ゲンチョ モンミャクナイ チュウニュウジ ノ ADRIAMYCIN ノ ヤクブツ ドウタイ"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_02_02_04.pdf","filesize":[{"value":"446.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_02_02_04.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3264/files/AN10044054_02_02_04.pdf"},"version_id":"ebb920b5-cdc1-49c7-924f-7186be422db4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adriamyacin"},{"subitem_subject":"アドリアマイシン"},{"subitem_subject":"肝癌"},{"subitem_subject":"抗癌剤門脈内注入療法"},{"subitem_subject":"薬物動態"},{"subitem_subject":"pharmacokinetics"},{"subitem_subject":"intraportal injection chemotherapy"},{"subitem_subject":"liver tumor"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<原著>門脈内注入時のAdriamycinの薬物動態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<原著>門脈内注入時のAdriamycinの薬物動態"}]},"item_type_id":"10001","owner":"1","path":["314"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-08-21"},"publish_date":"2014-08-21","publish_status":"0","recid":"3264","relation_version_is_last":true,"title":["<原著>門脈内注入時のAdriamycinの薬物動態"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-10-11T07:44:39.667805+00:00"}