{"created":"2023-05-18T10:11:31.323728+00:00","id":3279,"links":{},"metadata":{"_buckets":{"deposit":"a1bc538f-362a-4ae8-803e-f6338e1d8b89"},"_deposit":{"created_by":1,"id":"3279","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3279"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003279","sets":["205:251:317"]},"author_link":["15657","15659","15660","15661","15658","15656"],"item_10001_alternative_title_1":{"attribute_name":"タイトル(別表記)","attribute_value_mlt":[{"subitem_alternative_title":"Role of Naturally Occurring Intimal Thickening at Arterial Bifurcation in Development of Diet-Induced Atherosclerosis"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"92","bibliographicPageStart":"81","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"山梨医科大学雑誌"},{"bibliographic_title":"山梨医科大学雑誌","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 洋二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡辺, 聡"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩戸, 忠"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"ウサギに高脂肪食を投与し,総頸動脈非分岐部と内・外頸動脈分岐部における組織反応を比較検討した。健常対照群の内・外頸動脈分岐部には,分流部に著明な,側壁には軽度な細胞・線維性内膜肥厚(分岐部丘)が存在した。しかし総頸動脈の非分岐部には内膜肥厚は終始認められなかった。120日間高脂肪食で飼育すると,分岐部においては,平滑筋細胞の増殖と膠原線維の増生を主体とした細胞・線維性内膜肥厚が形成され,泡沫細胞の占める割合は少なかった。一方,非分岐部においては,主として泡沫細胞から成る内膜肥厚が生じ,平滑筋細胞や膠原線維は僅少な成分であった。この組織像の違いを決定づけるものとして,分岐部内膜に存在する平滑筋細胞を挙げたい。脂質に富む血奨が内膜に浸潤したとき,そこに平滑筋細胞が存在すれば,これが増殖し,細胞・線維性成分の多い内膜肥厚を形成するが,筋細胞が内膜に存在しない場合には,scavenger cellであるmacrophageが内皮下に浸潤し,脂質を取り込み,泡沫細胞化し,泡沫細胞を主体とした内膜肥厚を生ずると考えられる。高脂肪食を投与後,比較的初期の変化を電顕的に観察した。7日後,分岐部分流部の分岐部丘を覆う内皮細胞には,細胞間接合部の限局性の嚢状の離開が見られ, 内膜の基質が増加した。21日になると内皮細胞間接合部の離開は増強し,内皮細胞に変性が認められ,内膜に泡沫細胞も出現した。したがって分岐部における粥状硬化性病変の最早期像は,内皮細胞傷害であるといえる。高脂肪食の投与により,分岐部の分流部に最も早く病変が生じたが,その理由として,分流部内皮に強く加わるとされているずり応力が高脂血症に","subitem_description_type":"Other"}]},"item_10001_full_name_24":{"attribute_name":"著者名(別表記)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"15659","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yoshida, Yoji"}]},{"nameIdentifiers":[{"nameIdentifier":"15660","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe, Satoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"15661","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Iwato, Tadashi"}]}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003272","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨医科大学医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10044054","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0025","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_4":{"attribute_name":"タイトルヨミ","attribute_value_mlt":[{"subitem_text_value":"ゲンチョ カユジョウ コウカ ノ ハッセイ シンテン ニオケル イワユル セイリテキ ナイマク ヒコウ ブンキブキュウ ノ ヤクワリ ニツイテ"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"AN10044054_01_03_03.pdf","filesize":[{"value":"6.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10044054_01_03_03.pdf","url":"https://yamanashi.repo.nii.ac.jp/record/3279/files/AN10044054_01_03_03.pdf"},"version_id":"6d6aea33-6ef0-4deb-a2ea-168c4c3fa783"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"高脂血症"},{"subitem_subject":"粥状硬化"},{"subitem_subject":"生理的内膜肥厚"},{"subitem_subject":"分岐部丘"},{"subitem_subject":"Hyperlipidemia"},{"subitem_subject":"Atherosclerosis"},{"subitem_subject":"Naturally occurring intimal thickening"},{"subitem_subject":"Bifurcation pad"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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