{"created":"2023-05-18T10:11:55.362776+00:00","id":3764,"links":{},"metadata":{"_buckets":{"deposit":"a83cc9fc-a10d-4061-a9e4-c1d4cfe478d0"},"_deposit":{"created_by":5,"id":"3764","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"3764"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003764","sets":["205:357:359"]},"author_link":[],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"19","bibliographicPageStart":"15","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"山梨肺癌研究会会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of the Yamanashi Society for Lung Cancer","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内田, 賢典","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"飯島, 裕基","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"小林, 洋一","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"筒井, 俊晴","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"柿崎, 有美子","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"宮下, 義啓","creatorNameLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"要旨:現状でのEGFR遺伝子変異別の治療状況、効果予測因子について調査することを目的とし、2008年1月1日から2015年12月31日までの8年間で治療を行ったEGFR遺伝子変異陽性肺がん90例を対象とし診療録べ一スの後ろ向き検討を行った。Exon19de1群は41例、L858R群は40例であり、L858R群と比べ、Exon19del群はOSの延長を認めたが、オシメルチニブ導入例10例を除外した71例でExon19del群とL858R群を比較するとOS延長の有意差は消失した。単変量解析で有意差を認めたMutation、PS≦1、stage、2種類目のTKIの使用、オシメルチニブの使用でCox比例ハザード回帰を行ったところ、PS≦1、オシメルチニブの使用で有意であり、Exon19del群とL858R群のOSの差は認めなかった。本検討において、EGFR遺伝子変異陽性進行非小細胞肺癌では診断時のstage　IVa、IVb、再発よりもPS≦1、オシメルチニブの使用の可否がより大きい予後因子となった。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003757","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨肺癌研究会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10355815"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-7053"}]},"item_10001_text_4":{"attribute_name":"タイトルヨミ","attribute_value_mlt":[{"subitem_text_language":"ja-Kana","subitem_text_value":"トウイン　ニ　オケル　TKI　チリョウ　オ　オコナッタ　EGFR　イデンシ　ヘンイ　ヨウセイ　ショウレイ　ノ　チリョウ　ジョウキョウ"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"haigan31-1-015to019.pdf","filesize":[{"value":"777.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"haigan31-1-015to019.pdf","objectType":"fulltext","url":"https://yamanashi.repo.nii.ac.jp/record/3764/files/haigan31-1-015to019.pdf"},"version_id":"0da2d9d8-cc0e-4f09-b023-d2300e7d457b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"非小細胞肺がん","subitem_subject_language":"ja"},{"subitem_subject":"遺伝子変異","subitem_subject_language":"ja"},{"subitem_subject":"EGFR-TKI","subitem_subject_language":"en"},{"subitem_subject":"T790M","subitem_subject_language":"en"},{"subitem_subject":"オシメルチニブ","subitem_subject_language":"ja"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"当院におけるTKI治療を行ったEGFR遺伝子変異陽性症例の治療状況","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"当院におけるTKI治療を行ったEGFR遺伝子変異陽性症例の治療状況","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["359"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-19"},"publish_date":"2018-06-19","publish_status":"0","recid":"3764","relation_version_is_last":true,"title":["当院におけるTKI治療を行ったEGFR遺伝子変異陽性症例の治療状況"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-10-11T07:47:41.371159+00:00"}