{"created":"2023-05-18T10:11:59.233037+00:00","id":3838,"links":{},"metadata":{"_buckets":{"deposit":"7ca2d8d9-9c35-45ec-9527-fef371401ec5"},"_deposit":{"created_by":5,"id":"3838","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"3838"},"status":"published"},"_oai":{"id":"oai:yamanashi.repo.nii.ac.jp:00003838","sets":["205:357:365"]},"author_link":[],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"10","bibliographicPageStart":"7","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"山梨肺癌研究会会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of the Yamanashi Society for Lung Cancer","bibliographic_titleLang":"en"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮澤, 正久","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"白岩, 聡","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"赤池, 英憲","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"三井, 文彦","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"國友, 和善","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"千須, 和寿直","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"巾, 芳昭","creatorNameLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"内容","attribute_value_mlt":[{"subitem_description":"症例は77歳女性。右肺上葉原発肺腺癌に対し手術を施行、病理病期はpTlbNlMO,stageIIAであった。術後4年目に右肺門部再発・両肺転移・骨転移をきたした。gefitinibを投与したところ病巣は速やかに縮小、効果は持続していたが、投与24カ月目よりCEAの上昇と画像所見の再増悪を認めた。投与30ヵ月目より病状は急速に進行、両側胸水の増量もみられた投与41カ月目に提出した胸水細胞診はclassV、EGFR遺伝子変異検査の結果、エクソン21のL858R変異およびエクソン20のT790M変異を認めた。再発後41カ月目に癌死となった。gefitinib投与前はL858R変異のみを認めgefitinibが奏効したが、治療過程で耐性遺伝子変異(T790M)が出現し臨床的にも耐性となったものと推察された。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34429/00003831","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山梨肺癌研究会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10355815"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-7053"}]},"item_10001_text_4":{"attribute_name":"タイトルヨミ","attribute_value_mlt":[{"subitem_text_language":"ja-Kana","subitem_text_value":"EGFR TKI タイセイ イデンシ ヘンイ オ ミトメタ ハイガン ジュツゴ サイハツ ノ 1ショウレイ"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-27"}],"displaytype":"detail","filename":"haigan25-1-007to010.pdf","filesize":[{"value":"674.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"haigan25-1-007to010.pdf","objectType":"fulltext","url":"https://yamanashi.repo.nii.ac.jp/record/3838/files/haigan25-1-007to010.pdf"},"version_id":"568f0441-af65-4aa8-bc56-5f46366b2ac9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"EGFR-TKI","subitem_subject_language":"en"},{"subitem_subject":"耐性","subitem_subject_language":"ja"},{"subitem_subject":"肺癌","subitem_subject_language":"ja"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"EGFR-TKI耐性遺伝子変異を認めた肺癌術後再発の1症例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EGFR-TKI耐性遺伝子変異を認めた肺癌術後再発の1症例","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["365"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-10-03"},"publish_date":"2012-10-03","publish_status":"0","recid":"3838","relation_version_is_last":true,"title":["EGFR-TKI耐性遺伝子変異を認めた肺癌術後再発の1症例"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-10-11T07:49:46.424719+00:00"}