@article{oai:yamanashi.repo.nii.ac.jp:00000812,
 author = {高野, 邦夫 and Atkinson, James B. and 多田, 祐輔},
 journal = {山梨医科大学紀要, Bulletin of Yamanashi Medical University},
 month = {},
 note = {Prognosis of short bowel syndrome in infancy improved with the development of long-term parenteral nutrition(PN) and Home PN. Despite those results, some patients would greatly benefit by receiving a small intestine transplant becausce of an extreremely short bowel or severe motor dysfunction of remaining gut. Over 30 Tears ago Dr. Lillehei and colleagues from Minneapolis carried out experiments demonstrating that, from a technical point of view, transplantation of the gut was feasible, however, it rapidly became clear that compared with other forms of organ grafting there were major difficulties in achieving successful allogeneic small bowel transplantation. A number of patients were transplanted ill the 1960s and 1970s, but no long-term survival was achieved. In most of these cases death occured from rejection and septicaemia as a result of bacterial transplantation. In the 1980s the advent of cyclosporin, with its specific effects, rekindled interest ill the posibility of small bowel transplantation. In experimental animal models cyclosporin was capable of completely subverting the rejection response. And a small number of clinical intestinal grafts have been performed with modost success. In recent years, the new agent FK5O6 has shown promise in experimental studies. Furthermore Dr. Starzl, Dr. Todo and their colleagues from Pittsburgh have reported succesful clinical cases. Progress has been made towards developing a clinically successfu1 small bowel transplantation procedure. The field is moving very rapidly and within the next few years small bowel transplantation will be realistic alternative for patients currently, maintained on long term PN. In this paper, we report the research results of Childrens Hospital of Los Angeles small bowel transplant group and inform the presentation and discussion of the Second International Symposium on Small Bowel Transplantation in London, Canada, in order to discuss the current status and future prospects of small bowel transplant.},
 pages = {44--54},
 title = {小腸移植の現況と展望},
 volume = {9},
 year = {1992}
}