@article{oai:yamanashi.repo.nii.ac.jp:00000832,
 author = {浅香, 昭雄 and 飯島, 純夫 and 竹下, 達也 and 山縣, 然太郎 and 木之下, 徹},
 journal = {山梨医科大学紀要, Bulletin of Yamanashi Medical University},
 month = {},
 note = {Subjects were monozygotic twins. Aortic pulse wave velocity (PWV), blood pressure (BP) and bone mineral density (BMD) were examined. It was revealed that PWV, BP and BMD were all strongly determined by genetic factors. It is well known that PWV or BMD is an excellent indicator of arteriosclerosis or osteoporosis, respectively. For the early detection or prevention of these diseases it is necessary to examine PWV or BMD. At the same time, it was shown that risk factors in the environment were effectively clarified by use of twin method. BP was said to be influenced by additive genes. However, the effect of non-additive genes or single gene may play an important role for the value of BP as well as for the manifestation of hypertension, due to the present study, that is, by the newly designed maximum likelihood method. Monozygotic twins concordant or discordant for Alzheimer disease in the literature were analysed. The result indicated the presence of genetic heterogeneity of Alzheimer disease. Therefore, the strategy for the clarification of the disease should be made by different way according to the different mode of inheritance. Molecular genetic study was persuaded to the group which is under genetic control of a single dominant gene. Another approach shoud be the investigation of the risk factors in the environment for the group, which is caused by the effects of multifactorial inheritance.},
 pages = {20--26},
 title = {老化にみられる遺伝因子},
 volume = {7},
 year = {1990}
}