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<Original Article> Immunization with Rat Thyrotropin Receptor Peptides Corresponding to Two Specific Extracellular Domains Alters Thyroid Function in vivo
https://doi.org/10.34429/00003039
https://doi.org/10.34429/000030392dbdf90e-3133-4c58-a738-c9f98e253c8e
名前 / ファイル | ライセンス | アクション |
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AN10044054_12_04_03.pdf (680.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-11-09 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | <Original Article> Immunization with Rat Thyrotropin Receptor Peptides Corresponding to Two Specific Extracellular Domains Alters Thyroid Function in vivo | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | hyperthyroidism | |||||
キーワード | ||||||
言語 | en | |||||
主題 | thyrotropin receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題 | hypothyroidism | |||||
キーワード | ||||||
言語 | en | |||||
主題 | autoantibody | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003039 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
OHTA, Emiko
× OHTA, Emiko× ENDO, Toyoshi× OHMORl, Masayuki× OHNO, Makoto× ONAYA, Toshimasa |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The relationship between the specificities of rat thyrotropin receptor antibodies and their biological effects on the rat thyroid in vivo was studied. Sixteen male Wistar rats were immunized with one of two synthetic peptides; one corresponding to the N-terminal region, amino acid residues 29-57, termed RAT-N, and the other corresponding to the C-terminal region of the extracellular domain, amino acid residues 341-370, termed RAT-P. Rats immunized with RAT-N possessed thyroidstimulating antibody (TSAb) activity and significantly higher serum concentrations of 3, 5, 3'-tri-iodothyronine (T3) than those of the control groups. In contrast, antibodies generated in rats immunized with RAT-P posscssed TSH-binding inhibitor immunoglobulin (TBII) activity and lower T3, levels than those in the control group. Histologically, there were no inflammatory or destructive reactions in the thyroid glands of any of the rats. These findings suggest that thyrotropin receptor antibodies against the N-terminus have stimulatory effects on thyrocytes, and that antibodies generated against the C-terminal region of the extracellular domain play an inhibitory role in thyroid function in vivo. | |||||
言語 | en | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
ja : 山梨医科大学雑誌 en : Yamanashi medical journal 巻 12, 号 4, p. 143-150, 発行日 1997 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |