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As the fi rst step, we evaluated whether administering PDT for metastatic lymph nodes is possible in a rat model.Materials and Methods: Human lung squamous cell carcinoma (RERF-LC-AI) cells were subcutaneously injected into the foot pads of nude rats (F344/rnu-rnu) following X-irradiation. 3 mg/kg of Pba was injected around the tumors in the foot pads, and the Pba concentrations in the popliteal lymph nodes were measured chronologically from the absorption spectrum. The lymph nodes were irradiated with 670-nm light from a diode laser at 180 J/cm2 for 600 seconds and examined histologically.Results: The Pba concentrations in the lymph nodes reached a peak 40 minutes after local application and maintained approximately the same values until six hours. Widespread tumor cell necrosis was histologically evident in the specimens, and the relative proportion of the necrotic areas was 91.3 ± 8.1% (n=6).Conclusions: Our fi ndings suggest that Pba accumulates abundantly in metastatic lymph nodes following local administration into primary tumors and that administering PDT to treat the tumors is possible in a rat model.", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10001_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.34429/00002798", "subitem_identifier_reg_type": "JaLC"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "山梨大学医学会", "subitem_publisher_language": "ja"}]}, "item_10001_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11839837", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1348-5091", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-02-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "YMJ26-1-015to022.pdf", "filesize": [{"value": "4.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 4200000.0, "url": {"label": "YMJ26-1-015to022.pdf", "objectType": "fulltext", "url": "https://yamanashi.repo.nii.ac.jp/record/2805/files/YMJ26-1-015to022.pdf"}, "version_id": "3bbcb9e2-f81f-4394-8f29-71ccb6290434"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Lymphatic metastasis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pheophorbide a", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "photody-namic therapy", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Non-Small-Cell Lung Carcinoma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u003cOriginal\u003eA basic study of intraoperative photodynamic therapy for lung cancer : photodynamic therapy for lymphogenous metastases in nude rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "\u003cOriginal\u003eA basic study of intraoperative photodynamic therapy for lung cancer : photodynamic therapy for lymphogenous metastases in nude rats", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "5", "path": ["221"], "permalink_uri": "https://doi.org/10.34429/00002798", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2013-02-18"}, "publish_date": "2013-02-18", "publish_status": "0", "recid": "2805", "relation": {}, "relation_version_is_last": true, "title": ["\u003cOriginal\u003eA basic study of intraoperative photodynamic therapy for lung cancer : photodynamic therapy for lymphogenous metastases in nude rats"], "weko_shared_id": -1}
<Original>A basic study of intraoperative photodynamic therapy for lung cancer : photodynamic therapy for lymphogenous metastases in nude rats
https://doi.org/10.34429/00002798
https://doi.org/10.34429/00002798bd79ccaf-4957-4f76-a1c2-451077b34816
名前 / ファイル | ライセンス | アクション |
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YMJ26-1-015to022.pdf (4.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-02-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | <Original>A basic study of intraoperative photodynamic therapy for lung cancer : photodynamic therapy for lymphogenous metastases in nude rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Lymphatic metastasis | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Pheophorbide a | |||||
キーワード | ||||||
言語 | en | |||||
主題 | photody-namic therapy | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Non-Small-Cell Lung Carcinoma | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00002798 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
Mizutani, Eiki
× Mizutani, Eiki× Inoue, Hidenori× Shimada, Osamu× Matsubara, Hirochika× Kobayashi, Masami× Matsumoto, Masahiko |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background: We designed a new photodynamic therapy (PDT) protocol in which Pheophorbide a (Pba) accumulates in the lymph nodes following local administration around lung cancer tumors, followed by lobectomy and irradiation of the lymph nodes with lasers. As the fi rst step, we evaluated whether administering PDT for metastatic lymph nodes is possible in a rat model.Materials and Methods: Human lung squamous cell carcinoma (RERF-LC-AI) cells were subcutaneously injected into the foot pads of nude rats (F344/rnu-rnu) following X-irradiation. 3 mg/kg of Pba was injected around the tumors in the foot pads, and the Pba concentrations in the popliteal lymph nodes were measured chronologically from the absorption spectrum. The lymph nodes were irradiated with 670-nm light from a diode laser at 180 J/cm2 for 600 seconds and examined histologically.Results: The Pba concentrations in the lymph nodes reached a peak 40 minutes after local application and maintained approximately the same values until six hours. Widespread tumor cell necrosis was histologically evident in the specimens, and the relative proportion of the necrotic areas was 91.3 ± 8.1% (n=6).Conclusions: Our fi ndings suggest that Pba accumulates abundantly in metastatic lymph nodes following local administration into primary tumors and that administering PDT to treat the tumors is possible in a rat model. | |||||
言語 | ja | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 山梨大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1348-5091 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11839837 | |||||
書誌情報 |
ja : 山梨医科学雑誌 en : Yamanashi medical journal 巻 26, 号 1, p. 15-22, 発行日 2013 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |