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<Original Article> Inhibition of 7,12-Dimethylbenz(a)anthracene-induced Mammary Tumorigenesis by α-Linolenic Acid and Docosahexanoic Acid in Sprague-Dawley Rats
https://doi.org/10.34429/00003133
https://doi.org/10.34429/00003133eabf75f8-1477-4eff-9cd1-25eae0dbb3f1
名前 / ファイル | ライセンス | アクション |
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AN10044054_07_03_01.pdf (847.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-18 | |||||
タイトル | ||||||
タイトル | <Original Article> Inhibition of 7,12-Dimethylbenz(a)anthracene-induced Mammary Tumorigenesis by α-Linolenic Acid and Docosahexanoic Acid in Sprague-Dawley Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Mammary tumor | |||||
キーワード | ||||||
主題 | 7,12-Dimethylbenz(a)anthracene (DMBA) | |||||
キーワード | ||||||
主題 | α-linolenic acid | |||||
キーワード | ||||||
主題 | Docosahexanoic acid | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.34429/00003133 | |||||
ID登録タイプ | JaLC | |||||
著者名 |
YONEKURA, Ikumi
× YONEKURA, Ikumi× KANEKO, Takashi× ISODA, Yoshihiro× SATO, Akio |
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内容 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The effrcts of dietary ω-3 polyunsaturated fatty acid (ω-3 PUFA) on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors were studied in female Sprague-Dawley rats. Animals were maintained on a test diet containing corn oil [CO; linoleic acid (18:2 ω-6), 48.9%], perilla oil [PO; α-linolenic acid (18:3 ω-3), 54.1%] or fish oil [FO; docosahexanoic acid (22:6 ω-3), 40.1%] as fat (12% w/w each) for 60 days starting one week after DMBA was administered (10 mg/rat, po). The first tumor in both the PO and FO groups appeared 18 days later than that in the CO group. The mean latent period for tumorigenesis was significantly longer in the PO than in the CO group. As compared with rats in the CO group, fewer rats in the other groups developed tumors, those which did develop tumors had fewer tumors, and those tumors which did develop were smaller. These observations were consistent with the findings at autopsy. Linoleic acid content in the microsomes from tumor cells was significantly lower in both the PO and FO groups than in the CO group. However, the microsomes from the PO and FO groups had a markedly high content of α-linolenic acid and docosahexanoic acid, respectively. These findings suggest that the dietary ω-3 PUFAs, α-linolenic acid and docosahexanoic acid, inhibit the development of DMBA-induced mammary tumors by changing the fatty acid composition of biological membranes. | |||||
出版者 | ||||||
出版者 | 山梨医科大学医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0025 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044054 | |||||
書誌情報 |
山梨医科大学雑誌 en : 山梨医科大学雑誌 巻 7, 号 3, p. 79-87, 発行日 1992 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |