| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2009-03-13 |
| タイトル |
|
|
タイトル |
ステロイド治療による創傷治癒障害 : メカニズムの解明と治療法の展望 |
|
言語 |
ja |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
創傷治癒 |
| キーワード |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
サイトカイン |
| キーワード |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
ステロイド |
| キーワード |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
成長ホルモン |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
WOUND HEALING |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CYTOKINE |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CORTICOSTEROID |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
GROWTH HORMONE |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.34429/00000647 |
|
ID登録タイプ |
JaLC |
| タイトルヨミ |
|
|
|
ja-Kana |
|
|
ステロイド チリョウ ニヨル ソウショウ チユ ショウガイ メカニズム ノ カイメイ ト チリョウホウ ノ テンボウ |
| タイトル(別表記) |
|
|
その他のタイトル |
Mechanism of Adverse Effects of Longterm Corticosteriod Administration on Wound Healing; Changes of Cytokine Levels and Effect of Growth Hormone Treatment |
|
言語 |
en |
| 著者名 |
大矢知, 昇
蓮田, 憲夫
高野, 邦夫
腰塚, 浩三
武藤, 俊治
毛利, 成昭
荒井, 洋志
長阪, 智
宮原, 和弘
芹沢, 大
多田, 祐輔
|
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3829 |
|
|
姓名 |
TAKANO, Kunio(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3830 |
|
|
姓名 |
KOSHITUKA, Kozo(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3831 |
|
|
姓名 |
MUTO, Shunji(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3832 |
|
|
姓名 |
MOURI, Naruaki(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3833 |
|
|
姓名 |
ARAI, Hiroshi(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3834 |
|
|
姓名 |
OYACHI, Noboru(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3835 |
|
|
姓名 |
HASUDA, Norio(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3836 |
|
|
姓名 |
NAGASAKA, Satoshi(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3837 |
|
|
姓名 |
MIYAHARA, Kazuhiro(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3838 |
|
|
姓名 |
SERIZAWA, Masaru(en) |
| 著者名(別表記) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
3839 |
|
|
姓名 |
TADA, Yusuke(en) |
| 内容 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The purpose of our study is to clarify the mechanism of the adverse effects of administration of cortico steroids and the effects of human growth hormone (GH) in improving the wounds weakened by long term corticosteroid (CS) administration. Methods: I (epitherisation) ; Sprague-Dawley (SD) male rats were divided into four groups: group (G) 1 ; control, G2 ; covered with film dressing, G3; CS administration (dose, 2 mg/kg/d subcutaneously for 3 weeks preoperatively and throughout the postoperative). G4 ; CS administration and using film dressing In all animals, the operation consisted of making a circular skin defect of 3 cm diameter, which was covered with a film dressing. Time to 50% wound healing was recorded. II (epitherisation) ; Sprague-Dawley (SD) male rats were divided into four groups: group (G) 1 ; control, G2 ; CS administration (same dose as described) and G3 ; GH treatment (somatotropin, 1 IU/d postoperatively). G4 ; CS administration animals and GH treatment. In all animals, the operation consisted of making a circular skin defect of 3 cm diameter, which was covered with a film dressing. Time to 50% wound healing was recorded. III (remodeling) ; SD female rats were divide into four groups same as I. All animals underwent a precise 4 cm midline celioyomy which was closed using interrupted 4-0 monofilament nylon sutures. Wound bursting strength (WBS) was tested on postoperative day 6. Histology of wound and liver were evaluated. Cytokine concentrations in both wound exudate and serum were measured. Results: I; The times to 50% wound healing of G1, 3 and 4 were significantly shorter than G2. II; The times to 50% wound healing of G1, 3 and 4 were significantly shorter than G2. Interleukin (IL) -4 and IL-6 concentrations in the exudate of G2 were higher than those of other groups. III; The WBS's of G1, 3 and 4 were significantly greater than those of G2. Serum concentrations of TNF-β, INF-γ, IL-1β & IL-8 of G2 were higher than those of other groups. Conclusion: 1. CS administration not only impairs wo |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
山梨医科大学 |
|
言語 |
ja |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0910-5069 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10032951 |
| 書誌情報 |
ja : 山梨医科大学紀要
en : Bulletin of Yamanashi Medical University
巻 19,
p. 9-15,
発行日 2002
|
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
KJ00004287680.pdf (1.2 MB)
