| Item type |
デフォルトアイテムタイプ（梨大）(1) |
| 公開日 |
2025-01-08 |
| タイトル |
|
|
タイトル |
Association between filaggrin gene mutations and the clinical features of molluscum contagiosum: The Yamanashi Adjunct Study of the Japan Environment and Children's Study |
|
言語 |
en |
| 作成者 |
Kojima, Reiji
三宅, 邦夫
篠原, 亮次
久島, 萌
由井, 秀樹
小田和, 早苗
堀内, 清華
横道, 洋司
Akiyama, Yuka
大岡, 忠生
山縣, 然太朗
the Yamanashi Adjunct Study of the Japan Environment and Children's Study Group
| en |
the Yamanashi Adjunct Study of the Japan Environment and Children's Study Group
|
Search repository
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Creative Commons Attribution 4.0 International (CC BY 4.0) |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2024 The Authors |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
atopic dermatitis |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
filaggrin gene mutations |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
molluscum contagiosum |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
time to resolution |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
treatment modalities |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Previous studies have reported swimming, atopic dermatitis, and filaggrin (FLG) gene mutations as risk factors for molluscum contagiosum (MC) infection. FLG gene mutations impair skin barrier function. The aim of this study was to determine the impact of FLG mutations on the incidence and clinical features of MC. We used data from 2036 children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study, a prospective, birth cohort study. A questionnaire for caregivers (when children were 4 and 8 years of age) asked about clinical features including previous MC incidence and treatment, number of MC lesions at first visit, and time to resolution. Participants underwent genotyping to detect six FLG mutations that are common in the Japanese population. A logistic regression model was used to analyze the association between MC incidence and FLG mutations, adjusted for potential confounders. The cumulative incidence of MC at age 8 years was 47.1%. Among participants with a history of MC, 67.6% had undergone curettage. FLG mutation was a significant risk factor for MC incidence (adjusted odds ratio [aOR] 1.69, 95% confidence interval [CI] 1.18–2.42). Swimming and atopic dermatitis were also significant risk factors for MC. There was no significant association between FLG mutation and the number of MC lesions at the first visit or the time to resolution of lesions. FLG mutation is a risk factor for MC incidence; however, FLG mutations do not affect the number of MC lesions at presentation or the time to resolution. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
John Wiley & Sons Australia |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japanese Dermatological Association |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子（シンプル） |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ（シンプル） |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/1346-8138.17157 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-2407 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1346-8138 |
| 書誌情報 |
en : The Journal of Dermatology
巻 51,
号 4,
p. 484-490,
発行日 2024-04-02
|
Journal of Dermatology51_4_484.pdf (824 KB)
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